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Drug designing is one of the essential components for drug discovery process. Drug Screening predicts the binding energy of the lead molecule to the target & the thermodynamic properties. Molecular mechanics/Molecular dynamics is the most used methods to predict the model conformation changes
This session will discuss the practical difficulties in drug targeting and designing and approaches to overcome them.
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Pharmacokinetic activity depends on the amount of drug levels at the target site . Recent advances in analytical and quantitative methodologies are often non-invasive assessments of drug pharmacokinetics at the site of action for better understanding of pharmacokinetic properties.
Pharmacodynamics is affected by various factors including receptor binding and sensitivity, post receptor effects, chemical interactions, physiologic changes due to genetic mutations, diseases, aging, or impact of other drugs. Pharmacodynamics and pharmacokinetics explain the effects of drugs to the host body.
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The effect and response of drug varies for each individual due to variations in genome for each individual. Pharmacogenomics helps to analyse genetic effect of individuals in response of particular drug and gene-drug interactions in body.
Pharmacogenomics is the basis of personalized medicines, a relatively new concept and expected to flourish in the future.
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Pharmacology has evolved as a multi-disciplinary science with many sub-specialties including clinical pharmacology, cardiovascular pharmacology, behavioral pharmacology, neuropsychopharmacology, pharmacogenetics, and Pharmacoeconomics.
Pharmacology assess the positive effects of the drugs while toxicology deals with the negative effects of the drug as well as chemical substances and the means to ameliorate such effects.
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The physio-chemical and mechanical properties of the drug are indispensable in the preparation of the drug in pre-formulation studies. In dealing with protein pre-formulation, it is important to consider the solution behaviour of a given protein under different physiological conditions.
While formulating the drug, physio-chemical properties like particle size, polymorphism`, pH and solubility are should be taken into consideration as they impact bio availability and the activity of a drug. The formulation should ensure that the dosage should have a uniform appearance, acceptable taste and capsule disintegration properties.
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Clinical pharmacy and pharmacy practice play important roles in clinical trials and clinical research. In recent years pharmacist role in clinical research and patient care has improved significantly and they play active role in designing and modifying drug therapies. This session focuses on the recent advancements in clinical research and pharmacy practice.
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Pharmaceutical technology utilizes engineering and technology in different areas of pharmaceutical sector. It consists of methods, techniques, and handling of instruments in the formulation, manufacture, packaging, and logistics of drugs and other techniques used in diagnostic, determinative and medication procedures.
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Pharmaceutical microbiology and biotechnology have evolved as a useful field for the productions of biologic from microbial cells or animal or human cell lines. Biotechnological concepts and manipulations in the these filed has enhanced the production, variety and types of biologic produced. These field are expected to grow further in the future.
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Pharmaceutical and Medical chemistry are holistic scientific studies dealing with the interdisciplinary concepts that includes drug discovery, molecular mechanisms of pathogens, pharmaceutics, pharmacology, toxicology, organic chemistry and more.
Both fields as a whole provide better insights and understanding than individual studies towards the development of new drugs and therapeutics.
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This session deals with various technological developments in Bio-therapy for Cancer treatment, Chemotherapy and Immunotherapy, Bio-therapy in wound treatment, Radio-pharmaceuticals and Nuclear medicine.
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In recent years the research and development is focused much on innovative biologic and spurring the introduction and access to biosimilars. The FDA has issued several drafts and final guidance to assist biosimilar sponsors in generating data to support biosimilar applications. The FDA guidance and regulations provide insights regarding evaluation of biosimilars. The FDA is working to provide additional guidance on how biosimilar products could be designated to reference products. This session brings out the current, on-going researches and new regulations with respect to biologic and biosimilars.
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Phytochemicals and herbal medicines possess certain limitations like instability at high acidic pH, first-pass metabolism in liver, poor solubility and absorption problems. With the help of novel drug delivery systems first-pass metabolism, degradation in gastrointestinal tract, accumulation of the drug at non-targeted tissues are minimized with plant derived drugs with reduced side effects and improved therapeutic efficacy.
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This session deals with the major challenges in drug delivery systems such as delivery and bio-availability of poorly soluble drug compounds and inaccessibility of drug molecules to the target site. Other Major Challenges include biologic (peptides, proteins and DNA-based therapeutics) drug delivery, pediatric and geriatric drug delivery. Although certain strategies and approaches were developed to eliminate the problems in the drug delivery, they face certain shortcomings. With the help of new technologies it is possible to overcome such hurdles in drug delivery systems.
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New technologies and approaches are being developed to overcome the challenges in drug delivery. They are smart drug delivery systems, sustained release drug delivery, nano particle-based drug delivery systems, medical devices for drug delivery, drug delivery system for biologic and printing technology in dosage forms. These new methods are collectively called as drug delivery systems (DDS), which are based on multidisciplinary approaches that combine pharmaceutics, bio conjugate chemistry, molecular biology, pharmacology, polymer sciences, nanotechnology and electronics. A successful drug delivery system is the key for successful treatment of a diseases.
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Pharmaceutical nanotechnology offers innovative tools and technology, opportunities and scope in many areas of healthcare sector and it is now well-established as specialized area for drug delivery, diagnostics, prognostic and various treatment procedures through its nano-engineered tools and techniques.
It has a great impact in the future by overcoming the limitations of current technology in pharmaceutical sector.
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