The physio-chemical and mechanical properties of the drug are indispensable in the preparation of the drug in pre-formulation studies. In dealing with protein pre-formulation, it is important to consider the solution behaviour of a given protein under different physiological conditions.
While formulating the drug, physio-chemical properties like particle size, polymorphism`, pH and solubility are should be taken into consideration as they impact bio availability and the activity of a drug. The formulation should ensure that the dosage should have a uniform appearance, acceptable taste and capsule disintegration properties.
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