Scientific Program

Day 1

KEYNOTE SPEAKERS
  • Biodegradable polymers based Smart Nanocrystals for low water soluble drugs delivery

    Gomal University D.I Khan KPK,
    Pakistan
    Biography

    Dr. Barkat Ali Khan: Was born on 20 September 1982 in, Bannu, Khyber Pakhtunkhwa, Pakistan. He completed his B. Pharm. in 2005 from Gomal University D.I Khan, M. Phil. and PhD (Pharmaceutics) in 2010 and 2013 respectively from the Islamia University of Bahawalpur under the supervision of renowned professor Dr. Navid Akhtar. He is serving as associate Professor in the department of Pharmaceutics at faculty of Pharmacy, Gomal University D.I Khan, Pakistan, since January 2012. He also served the school of pharmacy, Kampala international university Uganda; east Africa for one year. He has more than 150 publications in national and international journals. He is the editor and associate editor of many Journals. He is serving as Editorial Board Member and reviewer for many reputed journals. He received scholarship for his master and PhD studies from the higher education commission (HEC) of Pakistan. He was granted travel expenses to present his research papers at Thailand, Sweden and Turkey by HEC.

    Abstract

    Nanocrystals are carrier-free, submicron-sized, colloidal drug delivery systems with particle sizes in the mean nanometer range. Nanocrystals have high bioavailability and fast absorption because of their high dissolution velocity and enhanced adhesiveness to cell membranes. Most nonsteroidal anti-inflammatory drugs belonging to the Biopharmaceutical Classification System II drug class, which are best candidates as the model drugs. The aim of nanocrystalization is to formulate nanocrystals using antisolvent technique or high shear homogenization to determine the effects of various stabilizers and processing conditions on the optimization of formula-tions. The various stabilizers which can be used are hydroxypropyl methylcellulose (0.5%), polyvinylpyrrolidone (0.5%), and sodium lauryl sulfate (0.1%). The various characterizations conducted for such research included stability studies at 25ºC and 4ºC, scanning electron microscopy, transmission electron microscopy (TEM), x-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), zeta potentials, polydispersity indexes, and dissolution studies. The dissolution rate and solubility of the formulated nanocrystals can be significantly enhanced. It can be concluded that selecting suitable stabilizers (i.e., polymers and surfactants) can produce stable nanocrystals, and this can potentially lead to a scaling up of the process for commercialization

  • Migratory birds travelling to Bangladesh are potential carriers of multi-drug resistant Enterococcus spp., Salmonella spp., and Vibrio spp

    Bangladesh Agricultural University
    Bangladesh
    Biography

    Dr. Md. Tanvir Rahman is a Professor in the Department of Microbiology and Hygiene, Faculty of Veterinary Science at Bangladesh Agricultural University. He is also the DIRECTOR of the Professor Muhammed Hussain Central Laboratory of Bangladesh Agricultural University. He is also an Adjunct Visiting Professor of Xinxiang University, Henan, China. Dr. Rahman completed DVM from Bangladesh Agricultural University , MSc from University of Guelph, Canada, PhD and University of Warwick, UK and Postdoc from the Max-Planck-Institute for Terrestrial Microbiology, Marburg, Germany.

    Abstract

    Antimicrobial resistance (AMR) is a major health crisis globally. Migratory birds could be a potential source for antibiotic resistant (ABR) bacteria, but nothing is known in this regard in Bangladesh. Here 66 freshly dropped fecal materials of migratory birds were analyzed. Bacterial isolation and identification were based on cultural properties and PCR. The disk diffusion method was employed to evaluate antibiogram profiles. By PCR, out of 66 samples, the detection rate of Enterococcus spp. (60.61%; 95% confidence interval: 48.55–71.50%) was found significantly higher than Salmonella spp. (21.21%; 95% CI: 13.08–32.51%) and Vibrio spp. (39.40%; 95% CI: 28.50–51.45%). Enterococcus isolates were frequently found resistant (100–40%) to ampicillin, streptomycin, meropenem, erythromycin, and gentamicin; Salmonella isolates were frequently resistant (72–43%) to chloramphenicol, tetracycline, ampicillin, streptomycin, and erythromycin; and Vibrio spp. isolates were frequently resistant (77–31%) to vancomycin, ampicillin, erythromycin, tetracycline, and streptomycin. In addition, 60% (95% CI: 44.60–73.65%) Enterococcus spp., 85.71% (95% CI: 60.06–97.46%) Salmonella spp., and 76.92% (95% CI: 57.95–88.97%) Vibrio spp. isolates were multi-drug resistant (MDR) in nature. Three isolates (one from each bacterium) were found resistant against six classes of antibiotics. The bivariate analysis revealed strong associations (both positive and negative) between several antibiotic pairs which were resistant to isolated organisms. This is the first study in detecting MDR Enterococcus spp., Salmonella spp., and Vibrio spp. from migratory birds travelling to Bangladesh. Frequent detection of MDR bacteria from migratory birds travelling to Bangladesh suggests that these birds have the potential to carry and spread ABR bacteria and could implicate potential risks to public health. We recommend that these birds should be kept under an AMR surveillance program to minimize the potential risk of contamination of the environment with ABR as well as to reduce their hazardous impacts on health.

Novel Drug Delivery Systems
Chair
Speaker
  • Student Speaker
    Anti-inflammatory effect of Baclofen through GABA receptors on acetic acid induced colitis in rat
    Speaker
    Azadeh Motavallian
    Erasmus MC University Medical center Rotterdam
    Netherlands
    Biography

    Azadeh Motavallian (Pharm D, PhD) has completed her PhD at the age of 28 years from Isfahan University of medical sciences, Iran. She is an assistant professor of Guilan University of Medical Sciences in Iran and now working as a postdoc fellowship in Erasmus University Medical Center in the Netherlands. She has more than 20 publications that have been cited over 340 times, and her publication H-index is 10.

    Abstract

    Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestinal tract whose etiology has not yet been fully elucidated and its treatment options have low efficacy and significant side effects. There is a pressing need for research to develop new effective drugs with lower adverse effects and more efficacy for treating IBD. The aim of the present study was to evaluate the anti-inflammatory effects of baclofen, a GABAB receptor agonist, on acetic acidinduced ulcerative colitis in rats and the probable involvement of GABA receptors. Twenty four hours before induction of colitis (intracolonic instillation of 2 mL of 3% acetic acid solution) to male Wistar rats, baclofen (5, 7.5, and 10 mg/kg; i.p.), Phaclofen (1mg/kg), Baclofen (10mg/kg) + phaclofen (GABAB receptor antagonist, 1mg/kg), and dexamethasone (1mg/kg) were administrated intraperitoneally (i.p) and continued daily for 3 days. Animals were thereafter sacrificed and the efficacy of baclofen on distal colon samples was investigated based on macroscopic assessment besides histological and biochemical findings [myeloperoxidase (MPO), tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta]. baclofen (7.5 and 10 mg/kg), and dexamethasone significantly decreased macroscopic and microscopic colonic lesions in rats compared with those in the colitis control group. These results were confirmed by reduced levels of MPO activity and colonic concentrations of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha, in the inflamed colon tissue. The beneficial effects of baclofen were antagonized by concurrent administration of phaclofen. The results of this study indicate that the protective effects of baclofen on acetic acid-induced colitis could be mediated by GABAB receptors.

  • Student Speaker
    In silico Design of RNA Aptamers for therapy, diagnosis, and drug delivery
    Speaker
    Muhammad Ashraf
    Ain Shams University, Egypt
    Egypt
    Biography

    Muhammad Ashraf is a graduate student with a BSc in Applied Biotechnology, who is interested in Bioinformatics and Pharmaceutical Biotechnology. Muhammad is focused on employing computational techniques to design and screen for new types of drugs and targeted therapies such as natural extracts from plants and microbes, RNA aptamers, and short peptides instead of conventional chemotherapies. Such products would have lower side effects and higher specificity toward their targets. In this manner, Muhammad has published a paper about RNA aptamers and currently working on another regarding natural products. Muhammad is always open to new ideas and projects to explore and work on with the aim of making a contribution to the progress in Pharmaceutical Biotechnology

    Abstract

    Aptamers, the single-stranded nucleic acid analogs of antibodies, hold a great promise in molecular diagnostics, therapeutics, and drug targeting, due to their sensitivity and high selectivity toward target molecules. Antibodies have significant disadvantages in their production, such as their costly synthesis, batch-to-batch variation, cross-reactivity, and the possibility of contamination. On the other hand, aptamers are easily synthesized and modified, with a high reproducibility. Owing to their smaller size than antibodies, aptamers have high biocompatibility, low immunogenicity and toxicity, and better transport and tissue penetration properties. Bioinformatic tools are comprised of a broad range of methods for aptamer design. Molecular modeling involves the prediction of the secondary structure of RNA from its primary nucleotides sequence, then, building a 3D tertiary structure based on this secondary structure. The predicted 3D model can then be used in docking simulations to investigate different poses of the RNA-protein interaction and select the complexes with the lowest binding energies. In the study, the tyrosine kinase domain of the NT-3 growth factor receptor was used as a target to demonstrate the potential of the bioinformatics methods as promising tools in the area of aptamer design and selection, by employing a complete set of in silico strategies for the development of aptamers, using a simple sequence-based procedure. As a result, a 69-nt aptamer was optimized to have a relatively stable structure and acceptable binding score to the target domain. Despite being simple, this method may contribute to the process of aptamer design in the future to reduce the number of sequences in the initial SELEX pool, by generating more sequences with similar nucleotides distribution or introducing minor mutations, or through coupling with other more sophisticated approaches.

  • Student Speaker
    Investigation of Ethyl Cellulose and Eudragit L100-55 blended nanoparticles for oral controlled delivery of Paclitaxel: In vitro and in vivo evaluation
    Speaker
    Dr. Mahvash Ansari
    Bahauddin Zakariya University Multan
    Pakistan
    Biography

    Mahvash Ansari is pharmacist by profession having post graduation research in novel drug delivery systems in MPhil and PhD. Having more than 10 year professional experience in area of teaching, research, regulation and quality control of medical products, currently leading NCL for Biologicals, Drug Regulatory authority of Pakistan, as Director and team lead for WHO-WLA. She is member of Federal Procurement Committee, Committee on availability of Essential medicine and audit team. Has national and international trainings on audit and quality of medical products and resource person for WHO and USP trainings. She is also guest lecturer at AKUH, NUMS and HSA.

    Abstract

    In this study, a series of pH sensitive polymeric nanoparticles using blend of ethyl cellulose and a commercially available poly (methacrylic acid-co-ethyl acrylate) derivative, Eudragit L 100-55, were synthesised to establish their potential use in oral delivery of Paclitaxel (BCS class IV drug). Prepared nanoparticles were characterized through various analytical techniques and in vitro dissolution studies were performed to confirm the pH dependent controlled release behavior. Optimised formulation was then subjected to single dose, non-compartment pharmacokinetic analysis in rabbits to further establish the potential of site specific and sustained drug release. FTIR confirmed the formation of co-polymeric network. DLS and SEM revealed round, smooth and somewhat uniformly distributed nanoparticles within the size range of 750 ± 1.81nm to 899 ± 1.25nm. Developed PTX- nanoparticles shown pH responsive drug release behavior with an ability to release drug in sustained fashion following non-Fickian diffusion mechanism. Pharmacokinetic profiling confirmed delayed release of drug with slow systemic absorption suggesting increased residance time of chemotherapeutic drug in lower part of GIT, which can be utilized for localized delivery of drug in colon to treat colorectal cancer.

  • Video Presentation
    Development of a biotechnical system for the automated incorporation of drug substances into human erythrocytes
    Speaker
    Dr Anna Suvorova
    Bauman Moscow State Technical University
    Russia
    Biography

    Anna Suvorova received her master's degree in 2018 from the Bauman Moscow Technical University and is currently a graduate student at the Faculty of Biotechnical Technologies of this university.

    Abstract

    Approach to combine drugs with erythrocytes is performed by means of forming transient pores in the erythrocyte membrane, thus allowing for the drug to enter the erythrocyte. In the process of dialysis, low molecular weight metabolites that are absent in a hypotonic solution can come out of the erythrocyte. The goal of drug development is to apply our technology into clinical practice. It requires a large-scale production of drug carries. Today there are 2 analogues of the device. ERYTECH Pharma based in Lyon (France) developed a therapeutic solution GRASPA for the treatment of acute lymphoblastic leukemia: positive results were obtained in children and adults as well as in elderly patients. Patients administered with homologous erythrocytes loaded with L-asparaginase GRASPA showed a reduction in the number and the severity of allergic reactions as compared to the free enzyme. EryDel, in Italy, has developed EryDex, a system to deliver dexamethasone at stable low systemic levels over an extended period of time. The biotechnical system for the detection of asparaginase in human erythrocytes includes a number of occurrences (?????????).

Medicinal Chemistry
Speaker
  • Plenary Speaker
    Chemical Composition and Biological Activity of Medicinal Products Growing In Egypt
    Speaker
    Dr Sahar Awadallah. M. Hussein
    National Research Center
    Egypt
    Biography

    Sahar .A.M. Hussein is Professor of natural product chemistry since 2004, She was the head of Phytochemistry and plant systematic department NRC. She was the head of NMR department at King Saud University, Riyadh Saudi Arabia. She joined DFG project. She was Co-principle investigator of Scientific Research Agreement BMBF, Germany . She was Co-principle investigator of STDF/DAAD-GESP. She focus in isolation, purification and identification of natural compounds from medicinal plants,using advanced techniques (1D and 2D NMR analysis), She is an editor of the Egyptian Journal of Chemistry and Open Medicinal Chemistry Journal. She awarded higher h-index 17 at NRC, she awarded scientific excellence at NRC. She has contributed 54 publications, having citations 1,231 with h-index 18

    Abstract

    Medicinal plants have been used as a source of therapies since ancient times in Egypt. Plant materials are very complex matrices. Plant polyphenols have drawn increasing attention due to their potent antioxidant properties and their marked effects in the prevention of various oxidative stress-associated diseases. In the present study, the Gossypium arboretum (cotton plant) was selected to determine the bioactive compounds from the crude methanol extract of seeds. Cotton belongs to the family Malvaceae, genus Gossypium; popularly known as white gold is an important commercial crop in Egypt. The seed extracts were prepared by using 70% methanol. The analysis methods include GC/Mass, HPLC/Mass, UV spectroscopy, and 1-D,2-D NMR spectroscopy. After illustrating the specific conditions of each analytical methods. Results revealed the presence of Phenolic, flavonoids, and their glycosides. On the other hand, the in-vitro anticancer effect of the methanol extracts from seed was evaluated for its antiproliferative potential towards different human cell lines, including colon (HCT116), liver (HEPG2), and breast (MCF7) cancer cell lines in comparison to Doxorubicin the traditional anticancer drug. The results showed that the in-vitro antiproliferative activity of methanol extract was significant and may be investigated for further in-vivo and pharmacokinetic studies. Furthermore, the anticancer effects of phenolics in-vitro and in-vivo animal models are viewed, including recent human intervention studies. Traditional folk remedies from plants have always guided scientists to search for new medications in order to maintain and promote a healthy life for humans

  • Plenary Speaker
    Pharmacological studies pertaining to spasmolytic, bronchodilator and vasodilating effect of Typha domingensis: An evidence-based approach.
    Speaker
    Dr. Mouqadas-Un-Nisa
    Bahauddin Zakariya University Multan
    Pakistan
    Biography

    Mouqadus-Un-Nisa has completed her PhD in 2020 at the age of 35 years in Pharmacology. She is Director of Drugs Testing Laboratory, Punjab, Multan and Drugs Testing Laboratory Punjab Bahawalpur. She is also a member of USP committee in Pakistan and has participated in different Trainings from LGC London, TMMDA Turkey, PFSA Pakistan and Dubai. She has a strong technical knowledge and have expertise in high-Tech Equipment like UPLC, HPLC, UV-VIS, Dissolution Apparatus and atomic Absorption Spectrometer. She has 06 publications with good impact factor. She teaches Pharmacology in TIMES Institute as a lecturer.

    Abstract

    This study was designed to analyze the pharmacological effects of Typha domingenesis crude 70% aqueousethanol extract of Typha domingensis (Td. Cr) in gastrointestinal, respiratory and vascular diseases. Rabbits (2.0-3.0 kg) and BALB/c mice (20-40 g) of local breed have been used as experimental animals using the established methodologies from literature with slight modification. The findings suggested that Typha domingensis caused complete relaxation of spontaneous and K+ (80mM)-induced contractions in isolated rabbit jejunum. Rightward parallel shift of calcium concentration response curves was observed. Typha domingensis exhibited relaxant effect on Carbachol (Cch)-induced contractions in isolated rabbit tracheal preparations. Furthermore, Typha domingensis caused relaxation of phenylephrine (1µM)-induced contractions in isolated rabbit aorta preparations. These effects were similar to verapamil, a standard calcium channel blocker. These findings could be the basis for explaining the spasmolytic, bronchodilator and vasodilator activities of the extract, through a possible calcium channel blocking activity.

Peptides and Protein Drug delivery
Speaker
  • Student Speaker
    An integrative ligand-based pharmacophore modeling, virtual screening, and molecular docking simulation approaches identified potential lead compounds against pancreatic cancer by targeting FAK1
    Speaker
    Mohammad Habibur Rahman Molla
    King Abdulaziz University
    Saudi Arabia
    Biography

    Mohammad Habibur Rahman Molla is pursuing his PhD in biology at King Abdulaziz University in Saudi Arabia. Strong researcher with a Bachelor of Science in Marine Sciences from the University of Chittagong in Bangladesh and a Master of Science in Aquaculture Technology from Pukyong National University in South Korea. He has been involved in vivo experiments on zebra fish since 2017. He has been doing his studies using several cancer cell lines (in vitro).

    Abstract

    Pancreatic cancer is a deadly disease with a 5-year survival rate, making it one of the leading causes of cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) is a ubiquitously expressed protein in pancreatic cancer. FAK, a tyrosine kinase that is overexpressed in cancer cells, is crucial for the development of tumors into malignant phenotypes. FAK functions in response to extracellular signals by triggering transmembrane receptor signaling, which enhances focal adhesion turnover, cell adhesion, cell migration, and gene expression. Until now, no effective drug candidates have been developed that can block the progression of the cancer caused by the FAK1. Therefore, the study aimed to identify potential drug candidates from the purchasable and natural compounds library, which will be able to block the c progression of cancer by inhibiting the activity of the FAK1. Initially, ligand-based pharmacophore approaches was applied to create a top ten best models. The best one model was utilized for the pharmacophore modeling and validation, pharmacophore-based virtual screening, virtual hit profiling, molecular docking, MD simulation, MM/GBSA and lead identification. Following the retrieval of twenty hits, four compounds were selected for further evaluation based on a molecular docking approach. Four newly discovered compounds, including Pubchem CID24601203, CID1893370, CID16355541, and ID16467343 with binding scores of -10.4, -10.1, -9.7, and -9.5 kcal/mol, respectively, may serve as lead compounds for the treatment of pancreatic cancer associated with FAK1. The ADME (Absorption, distribution, metabolism, and excretion) and toxicity analyses demonstrated that the compounds were effective and nontoxic. However, further evaluation through a wet lab is needed to determine the compounds' effectiveness.

  • Student Speaker
    Identification of Marine Fish Peptides as a Treatment Option Against the Multidrug-Resistant Acinetobacter baumannii
    Speaker
    Md Afsar Ahmed Sumon
    King Abdulaziz University
    Saudi Arabia
    Biography

    Md Afsar Ahmed Sumon is a PhD fellow in the marine biology department of the Faculty of Marine Sciences at King Abdul-Aziz University (KAU), Saudi Arabia. His current Ph.D. study focuses on the isolation of novel natural products from marine organisms and the development of anti-infective drugs for both aquatic and human infectious diseases. Additionally, he has published peer reviewed articles and is engaged in several collaborative research activities.

    Abstract

    Acinetobacter baumannii is one of the most dangerous multidrug resistant (MDR) pathogens with an immense ability to acquire or upregulate antibiotic drug resistance determinants. For MDR pathogens, antimicrobial peptides (AMPs) may be the last hope that they do not develop resistance easily. Fish peptides are essential to the survival of the fish as well as having critical functions in human physiology and pathophysiology. The identification of viable peptides from marine fish is a significant objective in drug research. It is necessary to study the interactions of specific peptides with the target protein to identify targeted therapeutics for antibiotic-resistant bacteria. The short-chain dehydrogenase/reductase (SDR) enzyme can play a role in the type II fatty acid synthesis (FASII) pathway, which is vital for a Gram-negative bacterium and inhibition of the protein can block the replication activity of the bacteria. Therefore, we intend to apply an in-silico technique to examine the new peptides as therapeutic candidates against A. baumannii by targeting the SDR protein. Initially, 34 peptides have been retrieved from marine fishes and docked against the SDR protein. Three peptides, namely Histone H2A (DRAMP18698), Piscidin-1 (DRAMP02330), and HKPLP (AP02038), have been selected based on their docking scores of ?258.4, ?250.4, and ?250.1 kcal/mol, respectively. Subsequently, the peptides were evaluated based on allergenicity and toxicity properties. The allergenicity and toxicity analyses revealed the efficacy and non-toxic properties of the peptides. Computational analysis revealed the virtuous value of the selected three peptides against the targeted protein that can be effective and promising antimicrobial resistance (AMR) drug candidates against the pathogen in a significant and worthwhile manner. Although in vitro and in vivo studies are required for further evaluation of the peptide against the targeted protein.

  • An integrative ligand-based pharmacophore modeling, virtual screening, and molecular docking simulation approaches identified natural lead compounds against lung cancer by targeting acetylcholinesterase
    Speaker
    Md Golap Hossain
    King Abdulaziz University
    Saudi Arabia
    Biography

    MD Golap Hossain is doing his PhD in King Abdulaziz University, Kingdom of Saudi Arabia where he will have the scope to utilize his potentiality and skills to do something innovative and from where he will be able to enhance his knowledge. On his position where he can utilize the best of his Technical and Research Skill, Academic Knowledge and Problem Solving Creativity. He want to further his knowledge to solve various problems of human civilization through proper research using the knowledge acquired during his study period

    Abstract

    Lung cancer is the most common cancer-related disease worldwide take millions of lives each year. Despite enormous efforts in lung cancer research, the incidence and mortality rates of lung cancer have not decreased substantially. Acetylcholinesterase (AChE) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters and causes cholinergic overstimulation. The overstimulation caused by AChE enzymes is responsible for enhancing the cell proliferation in lung cancer and inhibition of the enzyme can block the activity cell proliferation responsible for lung cancer. As inhibition of the protein can hinder the activity of the lung cancer, therefore the study aimed to identify potential natural inhibitor against the protein through ligand-based pharmacophore modeling (LBPM) and virtual screening approaches. Initially, 26 active compounds of the protein were retrieved from the ChEMBL database and a LBPM was generated followed pharmacophore model validation, virtual screening, molecular docking and ADME (absorption, distribution, metabolism, and excretion) and toxicity properties analysis. The best pharmacophore model was validated and used to screen 172324 natural compounds from ZINC natural product database. The pharmacophore model based virtual screening process identified of 155 hits, which was further screened through molecular docking. Based on the molecular docking simulation four compounds ZINC03848771, ZINC04293271, ZINC12893621 and ZINC04152233 were chosen, which has binding scores of -11.7, -10.8, -10.8, and -10.4 kcal/mol, respectively. Additionally, analysis of the ADME and toxicity properties demonstrated the efficacy and nontoxic properties of the selected compound. The integrated ligand-based drug design approaches identified four potential natural lead compounds that can inhibit the activity of the desire protein subsequently block the activity of lung cancer. However, in-vitro and in-vivo assay are suggested to confirm their activity against the targeted protein.

Tele pharmacy
Speaker
  • Virtual Speaker
    The rise of Telepharmacy services during the COVID-19 pandemic: A comprehensive assessment of services in the United Arab Emirates
    Speaker
    Dr Hala J. Al-Obaidi
    City University College of Ajman (CUCA)
    United Arab Emirates
    Biography

    Hala Al-Obaidi, an Assistant Professor, have a PhD. degree in Clinical and Pharmacy Practice from Queen’s University of Belfast – United Kingdom (2019), MSc. in Clinical Pharmacy from USM- Malaysia (2010) and a BSc. of Pharmacy from Ajman University-UAE (2005). I worked as a researcher (post-doc) in Clinical department, School of Pharmacy, in Ulster University - UK (2019). I have more than 12 year’s research experience and more than four years teaching experience in different universities in the UK and the UAE. I am interested in Telepharmacy, Telecare and innovation approaches that help improve medication management, adherence and wellbeing of the patients

    Abstract

    The study aimed to explore changes in community pharmacies’ processes in response to the pandemic in the United Arab Emirates (UAE) and factors affecting the adoption of these changes. Method: A cross-sectional study was conducted using a self-administered questionnaire that was distributed to licensed community pharmacists in the UAE. The survey used to collect information on the type of Telepharmacy services and related topics such as constraints and supports. The evaluation of services was done for three periods: before, during and after lockdown. Results: The number of completed surveys was 391. The majority of the participants were under 35 years old (79.5%), female (65.0%), with a bachelor’s degree (82.6%), and working in a pharmacy group (70.6%). Pharmacies provided the services by phone (95.6%) and/or messaging applications (80.0%) such as WhatsApp and Messenger. The community pharmacies provided a variety of services using Telepharmacy tools such as managing of mild diseases, dispensing and delivering prescribed and OTC medications, general health information, and services for patients with chronic disease. The main factors that had significant effects on several Telepharmacy services were pharmacies’ type (group/chain vs. individual) and the number of pharmacists in the pharmacy (p < 0.05). Lack of time, training and financial support were the main barriers associated with Telepharmacy services among individual pharmacies. Conclusion: Telepharmacy supported the work of community pharmacies during the COVID-19 pandemic by facilitating the provision of pharmaceutical services. Although the occurrence of several financial and technical problems, it appeared less frequently in pharmacy chains with a large number of pharmacists.

Drug Discovery and Development
Speaker
  • Virtual Speaker
    Cellular ribosome stress response with respect to drug development for cancer, cell damage and aging
    Speaker
    Dr Joon Kim
    Korea University
    South Korea
    Biography

    Prof KIM has been studying stress and DNA damage responses in human and yeast cells, supervised 40 PhD and 85 MS students and published about 200 papers. He graduated from Seoul National University (B.S. in Microbiology, 1981) and UC Berkeley (PhD in Biochemistry, 1989). He did his post-doc at Harvard Medical School. He has served as Presidents of Microbiological Society of Korea, and Federation of Korean Microbiological Societies. He also worked as Director of Division of Life Sciences, National Research Foundation of Korea, the national funding agency. He will serve as President of FAOBMB(Federation of Asian and Oceanican Biochemists and Molecular Biologists) until 2025.

    Abstract

    Our lab has identified that ribosome heterogeneity determines the function of each ribosome. Eukaryotic ribosomal protein S3 (rpS3) which switches its function as a DNA repair enzyme for damaged DNA when modified under various cellular stress conditions. Ribosomal protein S3 is a multifunctional protein working not only for translation but also for the prevention of DNA damage, cancer and aging processes. The function of rpS3 in the DNA repair processing is connected with cell viability and protein quality control. UV induced DNA damage is repaired by the nucleotide excision repair (NER) pathways; defects in these pathways lead to a genetic instability known as xeroderma pigmentosum (XP) eventually developing skin cancers. Here, we showed that XP-D cells overexpressing rpS3 showed markedly increased resistance to UV through XPD and rpS3 interaction thus augmenting the helicase activity of XPD protein, possibly preventing skin cancers. We also confirmed the DNA repair domain of rpS3 which can independently repair the damage DNA and facilitating the repair of damaged cells from skin, which could be used for anti-aging agent and cosmeceutics. It has been known that rpS3 has a metastasis inhibitory activity. We also identified the domain with an inhibitory effect on cancer cell metastasis which could be developed for anti-metastatic drugs. RpS3 has multiple extra-ribosomal functions through different post-translational modifications in humans and yeasts. This ribosome heterogeneity determines the fate of rpS3 between a ribosomal component for translation, and a stress response regulator to prevent cellular damage such as cancer, DNA damage and aging in general. Animal studies showed that this could be applied not only for the development of cancer drugs but also for cosmeceutics.

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