The physiochemical and mechanical properties of the drug is essential to choose the type of ingredients to be used in the preparation of the drug in pre-formulation studies. In dealing with protein pre-formulation, it is important to consider the solution behavior of a given protein under different physiological conditions.
During the formulation of drugs, physiochemical properties like particle size, pH, solubility and polymorphism are should be taken into consideration as they impact bioavailability and hence the activity of a drug. The formulation should be in such a way that the dosage should have a uniform appearance, acceptable taste and appropriate capsule disintegration properties.
- Active Pharmaceutical Ingredients
- Physiochemical Properties of drugs