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Speaker
Dr Sahar Awadallah. M. Hussein
National Research Center, Egypt
Biography

Sahar .A.M. Hussein is Professor of natural product chemistry since 2004, She was the head of Phytochemistry and plant systematic department NRC. She was the head of NMR department at King Saud University, Riyadh Saudi Arabia. She joined DFG project. She was Co-principle investigator of Scientific Research Agreement BMBF, Germany . She was Co-principle investigator of STDF/DAAD-GESP. She focus in isolation, purification and identification of natural compounds from medicinal plants,using advanced techniques (1D and 2D NMR analysis), She is an editor of the Egyptian Journal of Chemistry and Open Medicinal Chemistry Journal. She awarded higher h-index 17 at NRC, she awarded scientific excellence at NRC. She has contributed 54 publications, having citations 1,231 with h-index 18

Abstract

Medicinal plants have been used as a source of therapies since ancient times in Egypt. Plant materials are very complex matrices. Plant polyphenols have drawn increasing attention due to their potent antioxidant properties and their marked effects in the prevention of various oxidative stress-associated diseases. In the present study, the Gossypium arboretum (cotton plant) was selected to determine the bioactive compounds from the crude methanol extract of seeds. Cotton belongs to the family Malvaceae, genus Gossypium; popularly known as white gold is an important commercial crop in Egypt. The seed extracts were prepared by using 70% methanol. The analysis methods include GC/Mass, HPLC/Mass, UV spectroscopy, and 1-D,2-D NMR spectroscopy. After illustrating the specific conditions of each analytical methods. Results revealed the presence of Phenolic, flavonoids, and their glycosides. On the other hand, the in-vitro anticancer effect of the methanol extracts from seed was evaluated for its antiproliferative potential towards different human cell lines, including colon (HCT116), liver (HEPG2), and breast (MCF7) cancer cell lines in comparison to Doxorubicin the traditional anticancer drug. The results showed that the in-vitro antiproliferative activity of methanol extract was significant and may be investigated for further in-vivo and pharmacokinetic studies. Furthermore, the anticancer effects of phenolics in-vitro and in-vivo animal models are viewed, including recent human intervention studies. Traditional folk remedies from plants have always guided scientists to search for new medications in order to maintain and promote a healthy life for humans

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