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Biography

MD Golap Hossain is doing his PhD in King Abdulaziz University, Kingdom of Saudi Arabia where he will have the scope to utilize his potentiality and skills to do something innovative and from where he will be able to enhance his knowledge. On his position where he can utilize the best of his Technical and Research Skill, Academic Knowledge and Problem Solving Creativity. He want to further his knowledge to solve various problems of human civilization through proper research using the knowledge acquired during his study period

Abstract

Lung cancer is the most common cancer-related disease worldwide take millions of lives each year. Despite enormous efforts in lung cancer research, the incidence and mortality rates of lung cancer have not decreased substantially. Acetylcholinesterase (AChE) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters and causes cholinergic overstimulation. The overstimulation caused by AChE enzymes is responsible for enhancing the cell proliferation in lung cancer and inhibition of the enzyme can block the activity cell proliferation responsible for lung cancer. As inhibition of the protein can hinder the activity of the lung cancer, therefore the study aimed to identify potential natural inhibitor against the protein through ligand-based pharmacophore modeling (LBPM) and virtual screening approaches. Initially, 26 active compounds of the protein were retrieved from the ChEMBL database and a LBPM was generated followed pharmacophore model validation, virtual screening, molecular docking and ADME (absorption, distribution, metabolism, and excretion) and toxicity properties analysis. The best pharmacophore model was validated and used to screen 172324 natural compounds from ZINC natural product database. The pharmacophore model based virtual screening process identified of 155 hits, which was further screened through molecular docking. Based on the molecular docking simulation four compounds ZINC03848771, ZINC04293271, ZINC12893621 and ZINC04152233 were chosen, which has binding scores of -11.7, -10.8, -10.8, and -10.4 kcal/mol, respectively. Additionally, analysis of the ADME and toxicity properties demonstrated the efficacy and nontoxic properties of the selected compound. The integrated ligand-based drug design approaches identified four potential natural lead compounds that can inhibit the activity of the desire protein subsequently block the activity of lung cancer. However, in-vitro and in-vivo assay are suggested to confirm their activity against the targeted protein.

Special Issues
All accepted abstracts will be published in respective Allied Academies Journals.
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Terms and Conditions

Responsibility

Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.

Insurance

Registration fees do not include insurance of any kind.

Transportation

Please note that any (or) all transportation and parking is the responsibility of the registrant.

Press/Media

Press permission must be obtained from Allied Academies Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied academies are a non-profit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact the program manager to request a personalized letter of invitation via pharmaceuticalsciences@pharmaceuticsconferences.com

Regarding refunds, all bank charges will be for the registrant's account.

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to Program Manager (pharmaceuticalsciences@pharmaceuticsconferences.com or finance@alliedacademies.com).

Cancellation Policy

If Allied academies cancel this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Conferences (AAC) event which must occur within one year from the date of cancellation.

Postponement

If Allied academies postpone an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies Conferences event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization if registered person is unable to attend the event. Transfers must be made by the registered person in writing to Program ManagerDetails must be included with the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

  • Before 60 days of the conference: Eligible for Full Refund less $100 service Fee
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund less $100 service Fee
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits

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