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Dr. Barkat Ali Khan: Was born on 20 September 1982 in, Bannu, Khyber Pakhtunkhwa, Pakistan. He completed his B. Pharm. in 2005 from Gomal University D.I Khan, M. Phil. and PhD (Pharmaceutics) in 2010 and 2013 respectively from the Islamia University of Bahawalpur under the supervision of renowned professor Dr. Navid Akhtar. He is serving as associate Professor in the department of Pharmaceutics at faculty of Pharmacy, Gomal University D.I Khan, Pakistan, since January 2012. He also served the school of pharmacy, Kampala international university Uganda; east Africa for one year. He has more than 150 publications in national and international journals. He is the editor and associate editor of many Journals. He is serving as Editorial Board Member and reviewer for many reputed journals. He received scholarship for his master and PhD studies from the higher education commission (HEC) of Pakistan. He was granted travel expenses to present his research papers at Thailand, Sweden and Turkey by HEC.
Nanocrystals are carrier-free, submicron-sized, colloidal drug delivery systems with particle sizes in the mean nanometer range. Nanocrystals have high bioavailability and fast absorption because of their high dissolution velocity and enhanced adhesiveness to cell membranes. Most nonsteroidal anti-inflammatory drugs belonging to the Biopharmaceutical Classification System II drug class, which are best candidates as the model drugs. The aim of nanocrystalization is to formulate nanocrystals using antisolvent technique or high shear homogenization to determine the effects of various stabilizers and processing conditions on the optimization of formula-tions. The various stabilizers which can be used are hydroxypropyl methylcellulose (0.5%), polyvinylpyrrolidone (0.5%), and sodium lauryl sulfate (0.1%). The various characterizations conducted for such research included stability studies at 25ºC and 4ºC, scanning electron microscopy, transmission electron microscopy (TEM), x-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), zeta potentials, polydispersity indexes, and dissolution studies. The dissolution rate and solubility of the formulated nanocrystals can be significantly enhanced. It can be concluded that selecting suitable stabilizers (i.e., polymers and surfactants) can produce stable nanocrystals, and this can potentially lead to a scaling up of the process for commercialization